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Clinical Trial Planned for Tooth Regeneration Medicine
You or a family member may have “Congenital tooth defects” if any of the following apply to you
- After age 15, you still have baby teeth.
- You have a baby tooth that has fallen out and your permanent tooth has not come in.
- You have been told that you have six or more fewer teeth.
We are planning a clinical trial for the practical application of a therapeutic agent. If you think any of the above may apply to you, please click below to contact us.
About the clinical trial plan for the tooth regeneration treatment medicine
Our Technology
We are developing a tooth regeneration medicine
that grows the patient's own teeth
by approaching the tooth buds.
For research institutions and experts
For further more information ＞
For Patients
For further more information ＞
Working toward the development of the world's first new drug that “grows natural teeth”
CEO
Honoka KISO
Dentist, MD, Ph.D.
CTO
Katsu TAKAHASHI
Dentist, MD, Ph.D.
CBO
Muneo TAKATANI
Pharmacist, Ph.D.
Our Vision
Realization of a society where people are not afraid of losing their teeth
Our Mission
Extending the healthy life expectancy of people around the world through their own teeth and realizing a healthy and prosperous society.
We want to save people who are suffering from missing teeth.
Our technology is based on the research results of Dr.Katsu Takahashi, Associate Professor of Kyoto University (Dentist / currently Chief of Oral and Maxillofacial Surgery at Kitano Hospital, Tazuke Kofukai Medical Research Institute), who was engaged in the treatment of “congenital edentulism,” a condition that reduces quality of life (QOL) due to lack of teeth since childhood, and who conducted research on tooth regeneration. Based on research findings. In 2007, the research team encountered a model mouse with “excessive teeth,” in which tooth buds (tooth embryos/tooth crests), which should normally degenerate and disappear, grew and grew in the oral cavity. This led to the discovery that a “natural tooth-growing drug” could be developed if there were neutralizing antibodies that inhibited the molecules that inhibit the growth of tooth embryos.
Normal teeth
Excessive tooth
（Mouse teeth）
Dr.Katsu Takahashi, Associate Professor of Kyoto University
（Dentist / currently Chief of Oral and Maxillofacial Surgery at Kitano Hospital, Tazuke Kofukai Medical Research Institute）
The research team promoted research on the development of molecularly targeted drugs that grow new teeth by medicating the growth of tooth buds. It was shown that a neutralizing antibody preparation that suppresses molecules that inhibit the growth of tooth buds restores missing teeth in edentulous animal models. In May 2020, based on the results of his years of research, he established Toregem Biopharma, a start-up company from Kyoto University to develop a tooth regeneration treatment. First, the company is developing the world's first new drug that grows natural teeth with the aim of curing congenital edentulism, a condition that adversely affects nutritional security and growth due to missing teeth. In the future, we intend to expand the scope of application of the new drug to improve oral frailty (oral weakness) in the elderly.
